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Patil, Pramod
- Comparative Study of Generic and Branded Creams of Clotrimazole
Abstract Views :219 |
PDF Views:3
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli 415404, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli 415404, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 4 (2016), Pagination: 205-207Abstract
The present work deals with the comparative study of generic Clotrimazole cream and branded Clotrimazole cream. Generic drugs are copies of brand-name drugs having same dosage, same intended use, effects, side effects, route of administration risk, and safety strength as the original drug. In other words, their pharmacological effects are exactly the same as those of their brand-name counterparts. The present study includes the difference between branded and generic drugs, to check the efficacy of generic drug with respect to its price and to correct the misunderstanding about generic and branded drugs.Keywords
Clotrimazole Cream, Generic Drug, Branded Drug, Permeability, Antifungal Activity.- Design and Characterization of Sustained Release Aceclofenac Matrix Tablets Containing Tamarind Seed Polysaccharide
Abstract Views :171 |
PDF Views:0
Authors
Affiliations
1 Sree Siddaganga College of Pharmacy, B H Road, Tumkur- 572102, IN
1 Sree Siddaganga College of Pharmacy, B H Road, Tumkur- 572102, IN
Source
Asian Journal of Pharmacy and Technology, Vol 1, No 1 (2011), Pagination: 17-21Abstract
Sustained release formulation of Aceclofenac based on monolithic matrix technology was developed and evaluated. It is practically insoluble in water so it is suitable to develop sustained release matrix tablet using hydrophilic polymer. Aceclofenac is non-steroidal anti-inflammatory drug (NSAID) used extensively in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It is newer derivative of diclofenac and having less GIT complication, with short biological half-life 4 hrs, so developed formulation provides the advantages of sustained release formulations. The tamarind seed polysaccharide (TSP) was extracted from tamarind kernel powder and this polysaccharide was utilized in the formulation of matrix tablets containing Aceclofenac by wet granulation technique and evaluated for its drug release characteristics. TSP is a hydrophilic and rate controlling polymer. Granules were prepared and evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. Formulation was optimized on the basis of acceptable tablet properties (hardness, friability, drug content and weight variations), in vitro drug release and stability studies. All the formulations showed compliance with pharmacopieal standards. The in vitro release study of matrix tablets were carried out in phosphate buffer pH 7.4 for 12 hr. Among all the formulations, F 5 shows 98.062% better controlled release at the end of 12 hr. The results indicated that a decrease in release kinetics of the drug was observed by increasing the polymer concentration. The release data was fitted to various mathematical models such as, Higuchi, Korsmeyer-Peppas, First-order, and Zero order to evaluate the kinetics and mechanism of the drug release. The drug release of optimized formulations F-5 follows zero order kinetics and the mechanism was found to be diffusion coupled with erosion (non-Fickian diffusion/anomalous). The stability studies were carried out according to ICH guideline which indicates that the selected formulations were stable.Keywords
Aceclofenac, Extracted Tamarind Seed Polysaccharide, Matrix Tablet, Sustained Release, Wet Granulation.- Formulation and In Vitro Evaluation of Floating Matrix Tablets of Ofloxacin
Abstract Views :192 |
PDF Views:0
Authors
Pramod Patil
1,
B. Someshwara Rao
1,
Suresh V. Kulkarni
1,
Basavaraj
1,
Chetan Surpur
1,
Anand Ammanage
1
Affiliations
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN
1 Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H.Road, Tumkur-572102, Karnataka, IN